CD40LG and Thrombocytopenia: Our patient tested positive on IgG and IgM serology test, thus categorizing her with secondary dengue infection, which increases the risk for an exaggerated cytokine cascade response; this response was made clinically evident by severe thrombocytopenia (<50,000), elevated liver enzymes, mucosal bleeding, and massive plasma leakage which contributed to the development of acute pulmonary edema [8].