Because primary RPE undergo senescence in culture by passaging, we generated iPSCs from the RPE of AMD and normal donor eyes with CFH, HTRA1/ARMS2, LOC abnormal alleles, or with FACTOR B protective alleles, followed by differentiation into RPE (AMD RPE-iPSC-RPE and Normal RPE-iPSC-RPE) (Table 1). Here, CFH is linked to age-related macular degeneration.