SOD2 and age-related macular degeneration: We further performed functional analyses of AMD RPE-iPSC-RPE and AMD Skin-iPSC-RPE and observed increased susceptibility to oxidative stress, higher ROS production under oxidative stress, decreased mitochondrial activity, inability to increase SOD2 expression under oxidative stress conditions, and higher cytoplasmic glycogen as compared to normal RPE-iPSC-RPE.