However, we also found that the iPSC-RPE generated form RPE of normal donor harboring abnormal ARMS2/HTRA1 expression (Table 1), had the ability to increase SOD2 expression under oxidative stress condition, whereas the AMD iPSC-RPE generated from RPE of AMD donor with normal ARMS2/HTRA1 and with protective FACTOR B allele but with a history of heavy-smoking presented reduced ability to increase SOD2 levels under the same stress conditions. This evidence concerns the gene HTRA1 and age-related macular degeneration.