Consistently, in several solid tumors (such as prostate cancer, ovarian cancer and lung cancer), CDKN1A/p21 and CDKN1B/p27 were identified as EZH2 targets by ChIP-qPCR analysis, and inhibited due to elevated level of EZH2 [44–47]. The gene discussed is CDKN1B; the disease is Familial prostate cancer.