Specifically, EZH2 mediates the role of the MALAT1–PRC2 partnership in the epithelial–mesenchymal transition in renal cell carcinoma [22], whereas SUZ12 promotes the role of the MALAT1-PRC2 binding in tumor metastasis in bladder cancer [21]. The gene discussed is EZH2; the disease is hereditary clear cell renal cell carcinoma.