In the present study, our ChIP analysis demonstrated that EZH2 occupancy and H3K27me3 level at the promoter domains of p21 and p27 were both significantly decreased in MALAT1-deficient cells compared with control cells (P < 0.01), suggesting that overexpressed MALAT1 down-regulates p21 and p27, a process possibly mediated by EZH2-driven H3K27me3 in MCL. The gene discussed is CDKN1A; the disease is mantle cell lymphoma.