In summary, our results show that each tumor carried a unique set of genetic alterations and associated putative epitopes and that the construction of individual “cancer epitope trees,” together with the earliest genomic events, such as alterations in FBXW7, PIK3CA, and other members in the pathways, could assist in the understanding of the early genetic events involved in cervical carcinogenesis and, more importantly, the systematic search for optimal immunotherapeutic targets at the trunk or major branches. This evidence concerns the gene PIK3CA and neoplasm.