We also identified nine probably deleterious (CXCR4, IRS4, HCFC1, CTNND2, NRF1, PTPN13, PPP2R2B, MSRB2 and MYO1D) and two possibly deleterious de novo variants (EPHA10, PCNXL2) in genes that were also found with a frequency of >40% but had not previously been causally linked to AML/MDS. This evidence concerns the gene IRS4 and myelodysplastic syndrome.