We have identified 36 TFs whose regulons are significantly enriched for genes associated with breast cancer risk loci (termed “risk TFs”) [14], and four of these risk TFs (ESR1, FOXA1, GATA3 and SPDEF) have been identified as MRs of FGFR2-mediated risk in breast cancer [4]. The gene discussed is SPDEF; the disease is breast carcinoma.