INS and polycystic ovary syndrome: The pathway enrichment analysis conducted with the 1372 PCOS specific DEGs showed that these genes were specifically enriched in oocyte-follicle maturation and PCOS related pathways, such as MAPK signaling [23], TGFß signaling [24], insulin signaling [25], GnRH signaling [26] and Wnt signaling [27] pathways.