INS and diabetes mellitus: The KEGG (Kyoto Encyclopedia of Genes and Genomes) [22] pathway enrichment results showed that most PCOS-specific DEGs were significantly enriched (p<0.0225) in PCOS-related pathways like MAPK (Mitogen-Activated Protein Kinase) signaling pathway, TGF-beta signaling pathway, diabetes mellitus related pathways, insulin signaling pathway, oocyte-cell maturation pathways and hormonal signaling pathways (Fig 2).