F2 and Thrombocytopenia: When binomial logistic regression analysis was performed using the 53,137 AFP measurements as dependent variable (≤ 10 ng/mL vs. > 10 ng/mL), the following factors were independently associated with elevated AFP levels during surveillance: development of HCC, presence of liver cirrhosis, elevated transaminase levels, decreased albumin levels, prolonged prothrombin time, thrombocytopenia, high HBV viral loads and status of NA treatment (Table 2).