LOXL-2 was suggested to be specifically involved in cell adhesion and senescence in earlier study and recently, it was proved as a role in regulating angiogenesis through collagen IV scaffolding[43] and to participated in the mechanisms in many tumors and carcinoma, like the effect on proliferation of hepatocellular carcinoma, mediating transition and proliferative growth of dormant tumor cells, and drive lung cancer invasion and metastasis[44–46]. The gene discussed is LOXL2; the disease is lung cancer.