These patients covered all known genetic subtypes including two early thymic progenitor ALL (ETP-ALL) cases; cases harboring TLX3 (five cases), TLX1 (one case), NKX2-1 (one case), HOXA (one case), KTM2A/MLL (one ETP-ALL case), or TAL1 (one case) chromosomal rearrangements; and cases for which driving oncogenic events remain unknown (three patients, including one ETP-ALL case) [32]. Here, TLX1 is linked to acute lymphoblastic leukemia.