AKT1 and leukemia: Next, Meijerink and colleagues extended their analyses to 146 leukemia samples, for which they determined the mutational status of a selected panel of genes required for IL7R–RAS–MAPK–AKT signaling (IL7Ra, JAK1, JAK3, NF1, NRAS, KRAS, and AKT) by PCR-based Sanger sequencing.