The levels of Sam68, PAR, NF-κB activation, and anti-apoptotic molecules B-cell lymphoma-extra large (Bcl-XL) and X-linked inhibitor of apoptosis protein (XIAP) are elevated and positively correlated in colon tumors compared to adjacent normal tissue derived from either the tumor-laden Apcmin716/+ mice or human colon cancer patients. The gene discussed is XIAP; the disease is malignant colon neoplasm.