Besides the recently revealed critical function of Sam68-dependent NF-κB activation to overcome intrinsic DNA damage for the development and survival of colon cancer (Fu et al., 2016), whether Sam68-dependent NF-κB signaling is crucial in normal colon epithelium in response to extrinsic γ-irradiation remains elusive. Here, NFKB1 is linked to malignant colon neoplasm.