TFAP4 is a helix-loop-helix leucine zipper transcription factor and a target of MYC (Jung and Hermeking, 2009) that has been implicated in epithelial-to-mesenchymal transformation and metastasis in CRC (Jackstadt et al., 2013; Shi et al., 2014). Here, TFAP4 is linked to colorectal carcinoma.