HO-1 is upregulated in glia by oxidative stress, and HO-1 is expressed in oligodendrocytes in actively demyelinating areas in MS, but not in two other CNS diseases, human acute disseminated leukoencephalomyelitis (ADEM) or murine experimental allergic encephalomyelitis (EAE)29. This evidence concerns the gene HMOX1 and acute disseminated encephalomyelitis.