Furthermore, CAFs, which exhibit the traits of myofibroblasts, play a significant role in the promotion of growth and angiogenesis of tumor cells through their ability to secrete various extracellular matrix components, such as collagen, proteoglycans, proteases, growth factors, cytokines, and chemokines (e.g., stromal cell-derived factor 1 (SDF-1α))12. This evidence concerns the gene CXCL12 and neoplasm.