NAA50 and Anxiety: The gene separation anxiety (san) encodes Naa50/San, the catalytic subunit of NatE, a highly conserved NAT with a classical GNAT fold that acetylates N-termini starting with Methionine followed by hydrophobic (Met-Leu-, Met-Phe-, etc.)or small polar amino acids (Met-Ser-, Met-Thr-, etc.)21, 33, 34, 35.