As shown in Fig. 1A and B, from a panel of 55, only 4 factors (serpin E1, TIMP metallopeptidase inhibitor 1 (TIMP-1), urokinase plasminogen activator (uPA), and VEGF) were detectable in TIF derived from MCF-7_WT and MCF-7_VEGF tumors and the plasma from these tumor-bearing mice. The gene discussed is TIMP1; the disease is neoplasm.