Compared to the 10 proteins (GM-CSF, IGFBP-1, IGFBP-3, PTX-3, PDGF-AA, serpin E1, PEDF, TIMP-1, TIMP-4 and uPA) detected in the plasma of MDA-MD-231_WT tumor bearing mice, only 2 (serpin E1 and TIMP-1) were detected in the plasma of MCF-7_WT tumor bearing mice. Here, TIMP1 is linked to neoplasm.