RPGR and retinitis pigmentosa 1: Spanning all exons of RPGR and RP2 genes, the direct sequencing of PCR products of the proband with RP revealed the hemizygous status for a novel causative frame-shift mutation in exon ORF15 of RPGR gene (c.2091_2092insA [g.ORF15+338_339insA]; p.A697fs [p.ORF15+A112fs]) (Fig. 1J).