ILK and pancreatic insulinoma: Here we investigated the role of ILK in islet endocrine cells in vitro and in vivo and found that knockdown of Ilk in mouse insulinoma cells and deletion of Ilk in the pancreatic epithelium of mice reduce the adhesion strength of the endocrine cells to a vascular endothelial cell line, while at the same time increase cortex tension of the endocrine cells.