The verified (R47H and R62H) and possible (N68K, D87N and T96K) AD-risk variants all elute at the same volume as WT TREM2 (Figure 2—figure supplement 1g–l), suggesting that these mutations do not drastically alter the folding or oligomerization of TREM2 in solution. This evidence concerns the gene TREM2 and Alzheimer disease.