Moreover, the TRIAD3A variants have been proposed to affect gonadotropin‐releasing hormone (GnRH) secretion from the hypothalamus by the continuous activation and maintenance of NF‐κB signaling, resulting in hypogonadism (Chen et al., 2002; Miah et al., 2011; Margolin et al., 2013; Zhang et al., 2013). The gene discussed is NFKB1; the disease is hypogonadism.