SELP and Venous thrombosis: As per agents tested in our project, the above hypothesis agrees with results of other groups that showed either increased concentration of ICAM-1 and VCAM-1 in serum from varicose patients [37] or the relationship between elevated ICAM-1, VCAM-1, and P-selectin and the development of venous thrombosis [38, 39] and pulmonary embolism [40].