EDN1 and atherosclerosis: The lack of the correlation regarding P-selectin in varicose patients, in combination with positive relationships for ICAM-1, VCAM-1, and ET-1 (all are actively involved in atherosclerosis [44, 45]), implies that varicosity makes a serum more proinflammatory, and thus it may be partly responsible for the development of certain age-related pathologies.