EDN1 and chronic hepatitis B virus infection: In our previous animal studies, we found that EGB 761 can significantly decrease ET-1 levels in liver tissue(8), the present study showed the serum ET-1 level decreased significantly in patients with chronic hepatitis B after EGB 761 treatment, this implies the EGB 761 is capable of improving hepatic microcirculation and alleviating fibrosis acting as ET-1 antagonist.