INS and shigellosis: These KEGG pathways were involved in (1) metabolism of nutrients, including carbohydrate, protein, amino acid, and fatty acid, (2) signaling pathway, including signaling of insulin, ErbB, chemokine, calcium, and type II diabetes mellitus, (3) invasion of pathogenic factors, including bacterium, Escherichia coli, and Shigella (Shigellosis), and (4) endocytosis and phagocytosis.