Besides, miR-124-3p controlled glucagon release by directly targeting iGluR2 and iGluR3 [20]; miR-137 regulated proliferation and differentiation of human adipose tissue stromal cells by targeting CDC42 [21]; miR-135a-5p and miR-135b-5p controlled adipogenesis and atherosclerosis, respectively [22, 23]; miR-141-3p contributed to mitochondrial dysfunction in high-fat-diet induced obesity by inhibiting PTEN [24]. This evidence concerns the gene PTEN and obesity due to melanocortin 4 receptor deficiency.