Several polymorphisms in the aromatase or CYP19A1 have been reported to be associated with hormone-related disease such as osteoporosis and breast cancer (Masi et al., 2001; Somner et al., 2004; Talbott et al., 2008; Sergentanis and Economopoulos, 2010). The gene discussed is CYP19A1; the disease is breast cancer.