Combination of sodium butyrate together with a polyphenol, epigallocatechingallate (EGCG) proved to have synergistic effect against colon cancer as it induced significant degree of apoptosis, decreased colony forming capability of cancer cells by 80% and cell cycle arrest in different colon cancer cell lines (RKO, HCT-116 and HT-29). In addition to these, the expression of p21 and p53 were upregulated while HDAC and the caspase inhibitory protein, survivin were downregulated. This evidence concerns the gene HDAC9 and cancer.