A commercially available probiotic mixture VSL#3 and few strains of Bifidobacterium have been shown to produce CLA, a potent inducer of apoptosis, COX-2 inhibitor and activator of peroxisome proliferator-activated receptor gamma (PPAR γ) in colon cancer and have also been able to mitigate intestinal tumorigenesis in Apc-/+ mice (Davis and Milner, 2009; Urbanska et al., 2009; Uccello et al., 2012). Here, APC is linked to malignant colon neoplasm.