As shown in Figure 7, western blot analysis showed that TB up-regulated the protein expression of H2A.X (p-Ser139), P53, Bax, caspase 9, active-caspase 3 and cleavage-PARP and down-regulated the protein expression of Bcl-2 and pro-caspase 3. The gene discussed is CASP3; the disease is tuberculosis.