TP53 and tuberculosis: As shown in Figure 6, TB could significantly down-regulate the expression of TOPO I, TOPO II, and BCL-2 mRNA transcripts and up-regulate the expression of P53, GADD45, BAX, BIM, CASP 3, CASP 7, CASP 8, and CASP 9 mRNA transcripts in A549 cells when compared with the control group (all P < 0.01).