In addition, gene expressions of Topo I/II, E2f1, Gadd45, P53, Bax, Bcl-2, Bim, and Caspase 3/7/8/9 in A549 cells, which are involved in proliferation and apoptosis-associated process, were found modulated by TB (Figure 6). The gene discussed is CASP3; the disease is tuberculosis.