Although a causative role remains to be formally established, the facts that LBs/LNs are present in virtually all sporadic and familial forms of PD (Poulopoulos et al., 2012), that point mutations and multiplications of the αSyn-encoding gene, SNCA, lead to early onset PD (Polymeropoulos et al., 1997; Krüger et al., 1998; Singleton et al., 2003; Chartier-Harlin et al., 2004; Zarranz et al., 2004) and that SNCA polymorphisms positively correlate with PD risk (Satake et al., 2009; Simón-Sánchez et al., 2009; Edwards et al., 2010) attest an irrefutable link between PD and αSyn. Here, SNCA is linked to Parkinson disease.