Parkinson's disease (PD) is a complex degenerative disorder that is pathologically characterized by a massive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the progressive accumulation of Lewy bodies and Lewy neurites (LBs/LNs), two forms of inclusions rich in filaments of aggregated alpha-Synuclein (αSyn) (Spillantini et al., 1997). This evidence concerns the gene SNCA and Parkinson disease.