However, whether the antiatherogenic effects of Nkx2‐5 were partially mediated by cross‐talk between arteries and remote organs remained elusive, given that systemic adenovirus gene transfer actually affected various tissues and dynamic multiple organ cross‐talk in atherosclerosis has been paid much emphasis.57, 58 To further elucidate the effects of Nkx2‐5 on specific cell types of certain tissues, cell‐type–selective genetic manipulation should be taken into account in our future studies. This evidence concerns the gene NKX2-5 and atherosclerosis.