TP53 tumor-suppressor mutations, present in 50% of tumor cases in general, are less frequent in RCC (around 20% cases [154]), but confirmed in 786-O, A-498 (COSMIC and CCLE databases),,SN12C, TK10 [155] and reported as wild-type in ACHN, Caki-1, and Caki-2 [156]. The gene discussed is TP53; the disease is renal cell carcinoma.