Surprisingly, many basic pre-clinical RCC studies employing functional research on “renal cancer/renal carcinoma/renal adenocarcinoma/renal cell cancer” cell lines do not analyze the background of the investigated model and analyze different subtypes of RCC together, including wild-type cell lines and those harboring mutations (i.e. VHL) and cell lines of different histotypes [21–23]. Here, VHL is linked to renal cell carcinoma.