Nevertheless, the elevated level of Gr1+CD11b+ cell infiltration were observed in many other different models such as vesicular stomatitis virus (VSV) in melanoma and mesothelioma, Western Reserve strain VV (Vvdd) in AT-3, Reovirus in ovarian cancer pointing out these cells may play an important role in anti-VACV immune response [18, 32–34]. Here, ITGAM is linked to melanoma.