As it is shown in Fig. 4b, tumor cells co-incubated with iNOS+ MDSCs isolated from the spleen of GLV-2b372-treated mice had a higher apoptosis rate (39 ± 2.24%) as compared to the tumor cells co-cultured with iNOS+-MDSCs isolated from control mice (27 ± 1.69%). This evidence concerns the gene NOS2 and neoplasm.