A tumor-specific and metalloprotease-dependent NP-accumulation in the pancreatic tumor was observed by administration of vectorized NPs with outer shell REGAcp-PEGylated NPs (CAN-Mag@PNPs-PEG-REGAcp-PEG/tPA-pep1Lac) shown in the bottom part of Fig. 5b. This evidence concerns the gene PLAT and pancreatic neoplasm.