ADGRG2 and infection: Sparse methylation of a CpG island cannot cause transcriptional silencing of its downstream gene, but is important to induce dense DNA methylation of the CpG island, which can cause transcriptional silencing.25, 26, 27 Therefore, dynamics of sparse and dense DNA methylation according to different infection periods were analyzed for HE6 and SA9 by bisulfite sequencing combined with next‐generation sequencing.