Similar to TGF-β1-treated HFFF2, SMA-positive cells generated through senescence were contractile (Fig. 2H) and supported Transwell migration of tumor cell lines from cancers of the head and neck (HNSCC, 5PT) and esophagus (EAC, OE33) (Fig. 2I). Here, TGFB1 is linked to neoplasm.