In addition to its role as adaptor in the cytokine signaling pathway, Tab2 displays regulatory roles in transcriptional repression, in conjunction with the NCoR corepressor complex, in different contexts such as NF-kB regulated genes [5], astrocyte-specific genes in neuronal precursors [6] and prostate and breast cancer cells, where Tab2 mediates reversion of steroid receptor antagonists effects in response to inflammation [7,8]. The gene discussed is TAB2; the disease is breast cancer.