Reductions of SERCA2a protein expression and activity, and an enhancement of inhibitory effect of PLN are associated with impaired SR Ca2+ uptake in cardiomyocytes of HF, subsequently decrease Ca2+ release from SR to cytosol via ryanodine receptor, which induces the reduction of both systolic and diastolic function and, eventually cardiac death [14–16]. This evidence concerns the gene PLN and hydrops fetalis.