In the experiment of the measurement of cardiac function, we observed that PLN homozygous KO/CSQ-Tg mice showed less incidences of arrhythmia compared to PLN WT/CSQ-Tg mice (data not shown), suggesting that anti-arrhythmic effects of PLN ablation would also contribute to the improvement of mortality in CSQ-Tg mice. This evidence concerns the gene PLN and cardiac arrhythmia.