Methylation levels in the SPINT1 gene promoter region were also higher in the aMCI and AD groups as compared with NCs (NC, 28.4 ± 2.2; aMCI, 44.4 ± 2.9; AD, 43.0 ± 2.5% [mean ± S.E.M.]). Here, SPINT1 is linked to Alzheimer disease.