However, we consider that urine OPN N-half concentration is not merely proportionally correlated with urine protein concentration, because i) OPN N-half could not be detected in plasma and ii) we demonstrated that urine OPN N-half concentration was high in LN patients with massive proteinuria, while it was low in DN patients with massive proteinuria (Fig 1B). This evidence concerns the gene SPP1 and lobular neoplasia.