However, we consider that urine OPN N-half concentration is not merely proportionally correlated with urine protein concentration, because i) OPN N-half could not be detected in plasma and ii) we demonstrated that urine OPN N-half concentration was high in LN patients with massive proteinuria, while it was low in DN patients with massive proteinuria (Fig 1B). The gene discussed is SPP1; the disease is liver dysplastic nodule.