VEGFA and neoplasm: Taking advantage of the critical role played by VEGF in tumor angiogenesis and the contextual regulation imparted by critical elements in the 5'- and 3'-UTRs of the VEGF mRNA on its production in the tumor cell, we initiated a drug discovery program using PTC Therapeutics’ proprietary GEMSTM technology phenotypic screening platform [24] to target the elevated VEGF production in tumor cells selectively.