In addition, these patients exhibited a higher frequency of DKA at disease onset, a lower WHtR, acanthosis nigricans in very few children according to Burke ́s scale, a lower frequency of a family history of obesity and/or T2DM, lower hs-CRP levels, higher HbA1C, lower FCP levels and IS classified as normal. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.