Using the same strategy incorporating 5 cytokine/inflammation markers (CCL2, CCL3, TNFα, IL6 and IL8) hierarchic cluster analysis could distinguish lean, NAFLD subgroups and decompensated NASH cirrhotics although more patients were misclassified (Fig 3B). The gene discussed is CXCL8; the disease is metabolic dysfunction-associated steatohepatitis.