Although we demonstrated the potency of the Dlk1-Dio3 locus derived miRNAs (miR-411 and miR-540-3p) to induce myotube hypertrophy using an in vitro model, muscular hypertrophy phenotype observed in the callipyge mutation and myostatin deficiency would be caused by slightly different mechanism. Here, DIO3 is linked to hyperinsulinemic hypoglycemia, familial, 4.