Besides chromatin modification, MALAT-1 also functions as transcription regulator through activating Wnt signaling pathway, which results in increasing of ZEB1, ZEB2, Snail2 and decreasing of E-cadherin in bladder cancer, or suppressing PI3K-AKT pathway and inhibiting EMT in breast cancer [78, 79]. This evidence concerns the gene CDH1 and urinary bladder carcinoma.