KSR1 and central nervous system cancer: Interestingly, ectopic miR-34a was shown to sensitizecolorectal carcinoma cells to 5-fluorouracil [33]; meanwhile,miR-497 reduces tumor cell proliferation and sensitizes to 5-fluorouracil by inactivating KSR1 [34], and targets N-RAS to increase temozolomide-dependent apoptosis in gliomas [35].