No consistent single-nucleotide variations, copy number alterations by array comparative genomic hybridization or fusion transcripts were identified other than the Mll-AF9 fusion knock-in gene that is known to be present in both NRD and NRI AMLs (data not shown).8 NRI1 and NRI2 AML cells were more similar to each other than NRD AML cells as determined by unsupervised clustering. The gene discussed is KMT2A; the disease is acute myeloid leukemia.