The canonical nuclear factor-κB signaling pathway was activated in relapsed NRI AMLs compared with de novo NRD AML (z-score=2.111, P=1.479 × 10−4) and NFKB1 was among the predicted activated upstream regulators in relapsed NRI AML cells (z-score=2.603, P=2.000 × 10−4). Here, NFKB1 is linked to acute myeloid leukemia.