Overexpression of Ang-2 leaded to endothelial apoptosis, and promoted of expression of adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), thereby playing a crucial role in the progression of cardiac hypertrophy and interstitial fibrosis in animal model16. This evidence concerns the gene ANGPT2 and cardiac hypertrophy.