Two major TPO-RAs, romiplostim and eltrombopag, have been investigated in several randomized controlled trials (RCTs) involving adult and pediatric ITP patients9, 12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 24, 25, the results of which are encouraging. Here, TPO is linked to autoimmune thrombocytopenic purpura.