Moreover, we explored the role of intrarenal B-cell infiltration and related ELT formation, as well as an increase in serum CXCL13 levels in the pathogenesis, diagnosis, and treatment of LN; CXCL13 may function as a reliable and practical marker of serology and excessive ELT formation as a marker of histology for the clinical diagnosis of LN. Here, CXCL13 is linked to lobular neoplasia.