Serum CXCL13 levels in SLE patients (230.65 [145.92–365.40] pg/mL) were significantly higher than those of healthy individuals (85.13 [62.23–131.58] pg/mL) (Z = 4.42, P < 0.001). This evidence concerns the gene CXCL13 and systemic lupus erythematosus.