The Bruneck study (long-term, prospective, population-based study in the town of Bruneck located at the very north of Italy) reported an incidence rate of 7.6 per 1,000 person-years of T2DM in individuals aged 40–79 years and independent risk factors for incident DM as follows: impaired fasting glucose, overweight/obesity, insulin resistance, and impaired insulin response to oral glucose [6]. Here, INS is linked to type 2 diabetes mellitus.