Genes functionally interacting with TBX1, but mapping distal to this gene, such as CRKL and ERK2/MAPK1, have been proposed as candidate to CHD in this syndrome, in particular haploinsufficiency of MAPK1 gene, located between LCR22-4 and LCR22-5 (8). The gene discussed is TBX1; the disease is coronary artery disorder.